Effects of Myocardial Ischemia-Reperfusion on Autophagy of Brain Cells and the Intervention Effect of Propofol in Type 2 Diabetic Rats

To investigate the expression of autophagy markers brain cells and effect propofol on during myocardial ischemia-reperfusion in type 2 diabetic rats. 36 healthy male Sprague Dawley rats were randomly divided into 6 groups, each group, fed with high-sugar high-fat diet for 8 w intraperitoneal injection streptozotocin to prepare rat model diabetes. The groups are: sham operation ischemia reperfusion reperfusion+propofol normal operation, group[1]. In group reperfusion+ left anterior descending coronary artery was ligated 30 min reperfused h after injected mg•kg-1•h-1 10 min. Normal pumped 3 ml•kg-1•h-1 saline min, followed by ligation h. Arterial not performed groups. Brain tissue taken detect its levels mechanistic target rapamycin, phosphorylated mammalian rapamycin Beclin-1 Western blot. Compared level significantly decreased, beclin-1 increased other 5 (p<0.05). increased, while decreased Diabetes can promote aggravate injury. Propofol up-regulate Phosphorylated down-regulate alleviate damage